Abstract: The pathogenesis of iridocorneal endothelial (ICE) syndrome are dominated by the theory of viral infection and membrane theory of Campbell. And the theory combining the infectious of virus with integration of viral genes into human genome may provide new thinking. The present treatments of ICE syndrome are focus on corneal decompensation and secondary glaucoma. The endothelial keratoplasty is the main surgery for corneal endothelial decompensation and the attempt of artificial keratoplasty shows pretty good preliminary outcome. Secondary glaucoma is mainly treated by filtering glaucoma surgery while the explore of minimally invasive glaucoma surgery and glaucoma implant device in sulcus are started to treat secondary glaucoma of ICE syndrome. (Int Rev Ophthalmol, 2022, 46: 199-206)

Key words: iridocorneal endothelial syndrome, glaucoma